abstract：:In this review, I summarized transition in Dr. Marshall Nirenberg's research interests during 1970s, from a view of a long-lasting collaborator. Nirenberg switched his research filed to neurobiology after his success in deciphering genetic code and being honored with the Nobel Prize in Physiology or Medicine in 1968. ...

journal_title：Neurochemistry international

authors： Higashida H

更新日期：2012-11-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis is a devastating neurological disease that is inevitably fatal after 3-5years duration. Treatment options are minimal and as such new therapeutic modalities are required. In this review, we discuss the role of the myostatin pathway as a modulator of skeletal muscle mass and therapeutic ap...

journal_title：Neurochemistry international

authors： Walsh FS,Rutkowski JL

更新日期：2012-11-01 00:00:00

abstract：:Considerable evidence has been accumulated to suggests that blocking the inflammatory reaction promotes neuroprotection and shows therapeutic potential for clinical treatment of ischemic brain injury. Consequently, anti-inflammatory therapies are being explored for prevention and treatment of these diseases. Induction...

journal_title：Neurochemistry international

authors： Simão F,Matté A,Pagnussat AS,Netto CA,Salbego CG

更新日期：2012-10-01 00:00:00

abstract：:The differentiation of myelin-forming Schwann cells (SC) is completed with the appearance of myelin proteins MBP and P(0) and a concomitant downregulation of markers GFAP and p75NTR, which are expressed by immature and adult non-myelin-forming SC. We have previously demonstrated that holotransferrin (hTf) can prevent ...

journal_title：Neurochemistry international

authors： Salis C,Davio C,Usach V,Urtasun N,Goitia B,Martinez-Vivot R,Pasquini JM,Setton-Avruj CP

更新日期：2012-10-01 00:00:00

abstract：:Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

journal_title：Neurochemistry international

authors： Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

更新日期：2012-09-01 00:00:00

abstract：:Amyloid β (Aβ) oligomers are presumed to be one of the causes of Alzheimer's disease (AD). Previously, we identified the E693Δ mutation in amyloid precursor protein (APP) in patients with AD who displayed almost no signals of amyloid plaques in amyloid imaging. We generated APP-transgenic mice expressing the E693Δ mut...

journal_title：Neurochemistry international

authors： Takano M,Maekura K,Otani M,Sano K,Nakamura-Hirota T,Tokuyama S,Min KS,Tomiyama T,Mori H,Matsuyama S

更新日期：2012-08-01 00:00:00

abstract：:Synaptic degeneration is one of the earliest hallmarks of Alzheimer disease (AD) and results in loss of cognitive function. One of the causative agents for the synaptic degeneration is the amyloid β-peptide (Aβ), which is formed from its precursor protein by two sequential cleavages mediated by β- and γ-secretase. We ...

journal_title：Neurochemistry international

authors： Frykman S,Teranishi Y,Hur JY,Sandebring A,Yamamoto NG,Ancarcrona M,Nishimura T,Winblad B,Bogdanovic N,Schedin-Weiss S,Kihara T,Tjernberg LO

更新日期：2012-07-01 00:00:00

abstract：:Cerebral edema is a potentially life-threatening complication shared by diseases of different etiology, such as diabetic ketoacidosis, acute liver failure, high altitude exposure, dialysis disequilibrium syndrome, and salicylate intoxication. Pulmonary edema is also habitually present in these disorders, indicating th...

journal_title：Neurochemistry international

authors： Adeva MM,Souto G,Donapetry C,Portals M,Rodriguez A,Lamas D

更新日期：2012-07-01 00:00:00

abstract：:NADPH derived from glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, has been implicated not only to promote reduced glutathione (GSH) but also enhance oxidative stress in specific cellular conditions. In this study, the effects of G6PD antisense oligodeoxynucleotides...

journal_title：Neurochemistry international

authors： Zhao G,Zhao Y,Wang X,Xu Y

更新日期：2012-07-01 00:00:00

abstract：:Increased neurosteroids with allosteric modulatory activity on GABA(A) receptors such as 3α-5α tertrahydroprogesterone; allopregnanolone (ALLO), are candidates to explain the phenomenon of "increased GABAergic tone" in hepatic encephalopathy (HE). However, it is not known how changes of other GABA(A) receptor modulato...

journal_title：Neurochemistry international

authors： Ahboucha S,Talani G,Fanutza T,Sanna E,Biggio G,Gamrani H,Butterworth RF

更新日期：2012-07-01 00:00:00

abstract：:The mediatory role of kinins in both acute and chronic inflammation within nervous tissues has been widely described. Bradykinin, the major representative of these bioactive peptides, is one of a few mediators of inflammation that directly stimulates afferent nerves due to the broad expression of specific kinin recept...

journal_title：Neurochemistry international

authors： Guevara-Lora I

更新日期：2012-07-01 00:00:00

abstract：:NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable better control of ...

journal_title：Neurochemistry international

authors： Choo AM,Geddes-Klein DM,Hockenberry A,Scarsella D,Mesfin MN,Singh P,Patel TP,Meaney DF

更新日期：2012-04-01 00:00:00

abstract：:Neurodegenerative disorders are strongly associated with oxidative stress, which is induced by reactive oxygen species including hydrogen peroxide (H₂O₂). Epidemiological studies have suggested that coffee may be neuroprotective, but the molecular mechanisms underlying this effect have not been clarified. In this stud...

journal_title：Neurochemistry international

authors： Kim J,Lee S,Shim J,Kim HW,Kim J,Jang YJ,Yang H,Park J,Choi SH,Yoon JH,Lee KW,Lee HJ

更新日期：2012-04-01 00:00:00

abstract：:The role of glia maturation factor (GMF) in myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide-induced experimental autoimmune encephalomyelitis (EAE) was investigated using GMF-deficient (GMF-KO) mice. We demonstrate that GMF-KO mice were resistant to the MOG 35-55 peptide-induced EAE as compared to wild type (W...

journal_title：Neurochemistry international

authors： Zaheer S,Wu Y,Yang X,Ahrens M,Sahu SK,Zaheer A

更新日期：2012-02-01 00:00:00

abstract：:The carotid bodies (CBs) are chemosensory organs that respond to hypoxemia with transmitter neurosecretion, leading to a respiratory reflex response. It has been proposed that acetylcholine is a key regulator of transmitter release through activation of presynaptic nicotinic acetylcholine receptors (nAChRs). In the pr...

journal_title：Neurochemistry international

authors： Meza RC,Ortiz FC,Bravo E,Iturriaga-Vásquez P,Eugenín JL,Varas R

更新日期：2012-01-01 00:00:00

abstract：:Recent studies have suggested that neurosteroids such as pregnenolone, progesterone (PG) and their derivatives, have a role in activating autophagy in addition to diverse other functions. In our previous studies, we demonstrated that cellular free Zn(2+) is involved in oxidative stress-induced autophagy and autophagic...

journal_title：Neurochemistry international

authors： Kim HN,Lee SJ,Koh JY

更新日期：2012-01-01 00:00:00

abstract：:This study was aimed at examining the effect of tamoxifen, a selective estrogen receptor modulator, on the release of endogenous glutamate in rat cerebral cortex nerve terminals (synaptosomes) and exploring the possible mechanism. Tamoxifen inhibited the release of glutamate that was evoked by the K(+) channel blocker...

journal_title：Neurochemistry international

authors： Kuo JR,Wang CC,Huang SK,Wang SJ

更新日期：2012-01-01 00:00:00

abstract：:Lycopene is a potent free radicals scavenger with demonstrated protective efficacy in several experimental models of oxidative damage. Trimethyltin (TMT) is an organotin compound with neurotoxic effects on the hippocampus and other limbic structures and is used to model neurodegenerative diseases targeting these brain...

journal_title：Neurochemistry international

authors： Qu M,Zhou Z,Chen C,Li M,Pei L,Chu F,Yang J,Wang Y,Li L,Liu C,Zhang L,Zhang G,Yu Z,Wang D

更新日期：2011-12-01 00:00:00

abstract：:The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the glycine transporter 1 (GlyT1) and the clearance rate for glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the years, it has been shown that PKC tightly regulates the activity of several...

journal_title：Neurochemistry international

authors： Vargas-Medrano J,Castrejon-Tellez V,Plenge F,Ramirez I,Miranda M

更新日期：2011-12-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:Growing evidence suggests that α-lipoic acid (LA) has neuroprotective effects in various pathological conditions including brain ischemia and neurodegeneration. While anti-oxidative activity has been thought to play a central role in LA-mediated neuroprotection, the precise mechanism and the effect of LA enantiomers (...

journal_title：Neurochemistry international

authors： Yamada T,Hashida K,Takarada-Iemata M,Matsugo S,Hori O

更新日期：2011-12-01 00:00:00

abstract：:Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable agonists: Dpr(3)ghr ([Dpr(N-octanoyl)(3)] ghrelin) (Dpr - diaminopropionic acid), YA GHRP-6 (H-Tyr-Ala-His-DTrp-Ala-Trp-DPhe-L...

journal_title：Neurochemistry international

authors： Pirnik Z,Bundziková J,Holubová M,Pýchová M,Fehrentz JA,Martinez J,Zelezná B,Maletínská L,Kiss A

更新日期：2011-11-01 00:00:00

abstract：:Focusing on development of novel drug candidates for the treatment of neurodegenerative diseases, we developed and synthesized a new compound, 2-(cyclohexylamino)-1-(4-cyclopentylpiperazin-1-yl)-2-methylpropan-1-one (amido-piperizine 1). The compound demonstrated robust neuroprotective properties after both glutamate ...

journal_title：Neurochemistry international

authors： Elbrønd-Bek H,Wellejus A,Kelly NM,Weidner MS,Jørgensen SH

更新日期：2011-11-01 00:00:00

abstract：:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review...

journal_title：Neurochemistry international

authors： Obulesu M,Dowlathabad MR,Bramhachari PV

更新日期：2011-10-01 00:00:00

abstract：:Salsolinol (Sal), locally administered into the posterior VTA (pVTA) of rats, produces psychomotor responses and reinforcing effects, probably, through the activation of μ-opioid receptors (MORs). The neurochemical correlates of these phenomena are, however, practically unknown. In this paper, we explore the neurochem...

journal_title：Neurochemistry international

authors： Hipólito L,Martí-Prats L,Sánchez-Catalán MJ,Polache A,Granero L

更新日期：2011-10-01 00:00:00

abstract：:Neurons differentiated in vitro from embryonic stem cells (ESCs) have the potential to serve both as models of disease states and in drug discovery programs. In this study, we use sonic hedgehog (SHH) and fibroblast growth factor 8 (FGF-8) to enrich for forebrain and midbrain phenotypes from mouse ESCs. We then invest...

journal_title：Neurochemistry international

authors： Khaira SK,Nefzger CM,Beh SJ,Pouton CW,Haynes JM

更新日期：2011-09-01 00:00:00

abstract：:Neural stem (NS) cells are multipotent cells defined by their capacity to proliferate and differentiate into all neuronal and glial phenotypes. NS cells can be obtained from specific regions of the adult brain, or generated from embryonic stem cells (ESCs). NS cells differentiate into neural progenitor (NP) cells and ...

journal_title：Neurochemistry international

authors： Zeng WR,Fabb SR,Haynes JM,Pouton CW

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Neuronal iron accumulation is thought to be relevant to the pathogenesis of Parkinson's disease (PD), although the mechanism remains elusive. We hypothesized that neuronal iron uptake may be stimulated by functional mitochondrial iron deficiency. OBJECTIVE:To determine firstly whether the mitochondrial toxi...

journal_title：Neurochemistry international

authors： Carroll CB,Zeissler ML,Chadborn N,Gibson K,Williams G,Zajicek JP,Morrison KE,Hanemann CO

更新日期：2011-08-01 00:00:00

abstract：:Nitrite therapy is more effective in cerebral ischemia when administered earlier. It would be beneficial during the hyperacute stages of stroke if the nitrite effect is demonstrated in intracerebral hemorrhage (ICH). When nitrite is injected intravenously 3h after ICH induction in rats, most doses of nitrite provided ...

journal_title：Neurochemistry international

authors： Jung KH,Chu K,Lee ST,Kim JM,Park DK,Kim M,Lee SK,Roh JK

更新日期：2011-08-01 00:00:00

abstract：:D-aspartate is present in significant concentrations throughout the nervous tissue but its physiological role is still under discussion. Here, we report the process of d-aspartate release in retinal cells. [(3)H]-d-aspartate release occurs through a glutamate/aspartate exchange mechanism using excitatory amino acid tr...

journal_title：Neurochemistry international

authors： Stutz B,Yamasaki EN,de Mello MC,de Mello FG

更新日期：2011-06-01 00:00:00

abstract：:Following hemorrhagic stroke, red blood cells lyse and release neurotoxic hemin into the interstitial space. The present study investigates whether neurons can accumulate and metabolize hemin. We demonstrate that cultured neurons express the heme carrier protein 1 (HCP1), and that this transporter appears to contribut...

journal_title：Neurochemistry international

authors： Dang TN,Robinson SR,Dringen R,Bishop GM

更新日期：2011-06-01 00:00:00

abstract：:Tau isoforms constitute a family of microtubule-associated proteins that are mainly expressed in neurons of the central nervous system. They promote the assembly of tubulin monomers into microtubules and modulate their stability, thus playing a key structural role in the distal portion of axons. In Alzheimer's disease...

journal_title：Neurochemistry international

authors： Daccache A,Lion C,Sibille N,Gerard M,Slomianny C,Lippens G,Cotelle P

更新日期：2011-05-01 00:00:00

abstract：:Alzheimer's disease as well as prion-related encephalopathies are neurodegenerative disorders of the central nervous system, which cause mental deterioration and progressive dementia. Both pathologies appear to be primarily associated with the pathological accumulation and deposit of β-amyloid or prion peptides in the...

journal_title：Neurochemistry international

authors： Morte B,Martínez T,Zambrano A,Pascual A

更新日期：2011-05-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a novel neurotransmitter. We studied here the effect of ACS 84, a new H(2)S releasing compound, on the cytotoxicity induced by amyloid beta (Aβ) in microglia. Treatment with Aβ(1-40) (25μmol/L) for 24h significantly inhibited MTT reduction and increased lactate dehydrogenase release in BV-2...

journal_title：Neurochemistry international

authors： Liu YY,Sparatore A,Del Soldato P,Bian JS

更新日期：2011-04-01 00:00:00

abstract：:Aging is a biological process characterized by impairment of cellular bioenergetic function, increased oxidative stress, attenuated ability to respond to stresses, increased risk of contracting age-associated disorders that affects many tissues, with a more marked effect on brain and heart function. Oxidative stress i...

journal_title：Neurochemistry international

authors： Paradies G,Petrosillo G,Paradies V,Ruggiero FM

更新日期：2011-03-01 00:00:00

abstract：:The opening of pannexin-1 (Px1) hemichannels is regulated by the activity of P2X(7) receptors (P2X(7)Rs). At present, however, little is known about how extracellular ATP-sensitive P2X(7)Rs regulates the opening and closure of Px1 hemichannels. Several lines of evidence suggest that P2X(7)Rs are activated under pathol...

journal_title：Neurochemistry international

authors： Iwabuchi S,Kawahara K

更新日期：2011-02-01 00:00:00

abstract：:Cyclooxygenase 2 inhibitors (COX 2) such as parecoxib (par) and valdecoxib (val) are used in the treatment of neuropathic pain. Using the radioligand binding assay it was demonstrated that both the prodrug par as well as its active metabolite val have a specific affinity to the cannabinoid (CB) receptor measured in CB...

journal_title：Neurochemistry international

authors： Schröder H,Höllt V,Becker A

更新日期：2011-01-01 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stre...

journal_title：Neurochemistry international

authors： Horii-Hayashi N,Yoshikawa M,Matsusue Y,Ishizaka S,Nishi M,Wanaka A

更新日期：2011-01-01 00:00:00

abstract：:Excitotoxicity is the main event during neurological disorders producing drastic morphological and functional changes. Rac-GTPase is involved in cytoskeletal remodeling and survival. However, the role of Rac1 after cerebral ischemia has not been completely understood yet. In this study, we evaluated the activity of Ra...

journal_title：Neurochemistry international

authors： Johanna GV,Fredy CA,David VC,Natalia MV,Angel CR,Patricia CG

更新日期：2010-12-01 00:00:00

abstract：:We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with brain tissue assays and microdialysis; behavior was assessed as t...

journal_title：Neurochemistry international

authors： Bosker FJ,Tanke MA,Jongsma ME,Cremers TI,Jagtman E,Pietersen CY,van der Hart MG,Gladkevich AV,Kema IP,Westerink BH,Korf J,den Boer JA

更新日期：2010-12-01 00:00:00